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Figure 2 The GH-GHR interaction in granulosa cells can modulate FSH action and also induce the expression of LHR ( in vitro ( in vivo (Figure 1) ( GH was shown to promote androsterone and androgen synthesis in rat theca cells, and this response was independent of IGF production and cAMP accumulation (Figures 1, 2) ( in vivo / ex vivo studies in women with decreased ovarian reserve revealed that GH supplementation as part of IVF treatment, increased the expression of LHR, FSHR, and GHR in human granulosa cells isolated after egg collection ( Ovarian GH-IGF Axis Interaction of GH with GHR can activate canonical and non-canonical downstream signaling