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Introduction Thirty-four million children worldwide have hearing loss, with an estimated 60% of these cases potentially preventable ( Most of the existing literature addresses adults, focuses narrowly on the mechanism, or ignores the developmental pharmacology that makes pediatric patients different (Table 1)

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The MAPK/ERK cascade is activated by various extracellular stimuli and transmits signals from cell surface receptors to nuclear targets, regulating gene expression and cellular responses