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Clin Immunol (2004) 110(2):172–80.10.1016/j.clim.2003.11.007 28 SalujaRKetelaarMEHawroTChurchMKMaurerMNawijnMC

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The first and major contributor is impaired synthesis due to diminished availability of the amino acid precursors cysteine and glycine (compared with values reported in healthy controls) (20, 21), and the second is increased entrapment of GSH in its oxidized form

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