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NOXs have also been implicated in cellular signaling and regulation of multiple diverse biological outcomes, including cell proliferation, cell migration, immune cell activation, and metabolic adaptation

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For example, a ferroptosis-prone chondrocyte cluster with high expression of ACSL4 and Tf, but low expression of FTH1 and TRPV1, has been identified in severely degenerated cartilage regions ( We propose that selectively targeting ferroptosis in specific cell populations may enhance therapeutic precision