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Immune functions As among the most abundant intracellular proteins, HSP70s serve as signals of compromised cell integrity, namely, damage-associated molecular patterns (DAMPs), when released extracellularly (Kaneko et al., 1997)

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In the context of neurodegenerative diseases, the brain’s high oxygen consumption, abundant lipid content, and relatively low antioxidant capacity make it particularly vulnerable to oxidative stress [25,26,27]

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