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The ROS generated from aerobic respiration caused a cumulative oxidative damage in macromolecules, including lipids, DNA, and proteins, which subsequently lead to cells death (Scheibye-Knudsen et al., 2015), and affect the healthspan of numerous principal organ systems (Dai et al., An alteration of the redox status and the dysregulation of the immune system during aging may lead to the elevation of systemic inflammatory status

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We further identified the isocitrate lyase AceA and the myo-inositol-1-phosphate synthase Ino1 as abundant S- mycothiolated proteins in M