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ROS influence proteasomal, lysosomal, and mitochondrial function, which, in turn, regulate the cellular response to oxidative damage ( Parkin and PINK1 are localized in the mitochondria and their functions are tightly connected to the normal functioning of the mitochondria ( Drosophila , lacking, or deficient in parkin, exhibit mitochondrial deficits and high vulnerability to oxidative stress (Wood-Kaczmar et al., 2008)
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Alterations in carbohydrate and lipid metabolism coupled with electrolyte imbalances are likely to occur