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While physiological levels of ROS are required in the normal transition between wound healing phases, as previously described, an overproduction of ROS has deleterious effects and can hinder wound healing 159

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In contrast, anti-inflammatory approaches have produced the most consistent outcomes, including reductions in pro-inflammatory cytokines (IL-1β and TNF-α), elevations in anti-inflammatory mediators (IL-10 and LXA4), and structural restoration within the hippocampus and cerebellum, particularly increased neuronal density and Purkinje cell number