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Bone marrow-derived mesenchymal stem cells Upregulation of NPC proliferation, elevated type II collagen yield, downregulation of MMP-9 expression, and decreased TGF-β and nuclear factor-κB (NF-κB) signalling were discovered in pre-senescent NPCs in co-culture system of TNF-α-induced degradation of NPC through BM-MSCs (Fig

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