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The methylation-induced silencing of the tumor suppressor genes RASSF1 and RASSF2A , coupled with the subsequent activation of the Ras/PI3K/Akt signaling axis, constitutes the underlying mechanism of radioresistance in individuals with OSCC

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4.6 Phosphodiesterase inhibitors Pentoxifylline, a non-selective phosphodiesterase inhibitor, has shown modest clinical benefit in patients with moderate to advanced stages (188)