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Structure–Activity Correlation between Natural Glutathione Peroxidase (GPx) and Mimics: A Biomimetic Concept for the Design and Synthesis of More Efficient GPx Mimics - Mugesh - 2001 - Chemistry – A European Journal - Wiley Online Library

By further elucidating the pathogenic mechanism by which hepatic iron accumulation triggers ferroptosis through the c-Myc-Acsl4 regulatory axis, thereby accelerating the progression of metabolic-associated steatohepatitis (MASH), our research team identified a novel iron chelator, FOT1 (FerroTerminator1, formerly known as CN128), through drug screening, which can prevent and treat the onset and progression of MASH disease [117]

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