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Kinetic principles and analysis As reported previously (29, 32), the combined use of [1,2- 13 C 2 ]glycine and [ 2 H 3 ]leucine permits determination of the kinetics of whole-body glycine turnover, the conversion of glycine to serine, the rate of glycine decarboxylation, and its role as a source of 1-carbon units in 1-carbon metabolism