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Large-scale postmortem analyses indicate that cerebrovascular pathology occurs in approximately 80% of AD cases—a prevalence markedly higher than in other neurodegenerative disorders such as Parkinson’s disease, frontotemporal dementia, and Lewy body disease—highlighting a potentially distinctive role of vascular dysfunction in AD pathogenesis (161)

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Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin