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Nevertheless, such an appearance of peroxidized lipids is usually linked to a level of oxidative stress that may drive the onset of autophagy, mitophagy and aerobic glycolysis, resulting in the local production of high-energy mitochondrial fuels (such as L-lactate, ketone bodies and glutamine)
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Regardless, while the ferrohaem may not follow the same binding scheme as the ferrihaem, in either case the distal histidine and its protic environment is paramount as its absence in H64V Mb appears to interrupt the stepwise proton transfer(s), resulting in decreased NiR activity (Yi et al ., 2009)