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Given the differential effects of ML226 on 2-OGDD inhibition, we wanted to take an orthogonal approach to impairing OGDHc activity

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Ascorbate peroxidases (APX), a class I heme peroxidase familiar as ascorbate-dependent peroxidase, scavenges H 2 O 2 and senses redox alterations within plant cells, playing an essential role in the “Foyer-Halliwell-Asada pathway”