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Background: Parkinson’s Disease Dementia affects up to 31% of patients, with nearly half developing dementia within 10 years of diagnosis [1]

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To prevent inappropriate coagulation initiation, intact ECs express TF pathway inhibitor (TFPI), a serine protease that dampens activation of clotting through the extrinsic pathway by serving as a FXa-dependent inhibitor of the TF-FVIIa complex