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Thus, immune cells such as mast cells or enterochromaffin cells tend to overreact in the colonic mucosa, signaling inflammation to the ENS and further triggering the release of serotonin and several cytokines that mediate local ROS production

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Butyrate is the main energy source for colonocytes and it performs several important functions such as maintaining the integrity of the intestinal epithelial barrier, regulating mucosal immune homeostasis, suppressing colonic NF-κB-driven inflammation, inducing histone deacetylase inhibition, histone acetylation, gene expression changes, epigenetic gene regulation, and promoting apoptosis in pre-neoplastic colonocytes (50)