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Severe Gastrointestinal Disease, Gallbladder Problems, or Prior Pancreatitis These conditions are particularly relevant when considering GLP-1 or dual-incretin therapy

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SIRT1 deacetylates and activates key transcription factors such as FOXO and PGC-1α that promote neuronal survival and mitochondrial biogenesis, while SIRT3 enhances mitochondrial function and reduces oxidative stress in neurons