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16 It has been shown that chronic stress induces dysfunction of hypothalamic–pituitary adrenal (HPA) axis leading to elevation of cortisol which causes IR and abdominal adiposity

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The following describes the metabolic pathway and function of glycine in detail from multiple aspects: Glycine cleavage metabolism (GCS) The glycine cleavage system (GCS) is an important metabolic pathway in mitochondria, which is mainly responsible for converting glycine into 5-10 carbon compounds (such as 5-10 methyltetrahydrofolate and carbon dioxide) and provides a key intermediate for one-carbon metabolism