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The NIDDK overview of prescription weight management medications explains how GLP-1 receptor agonists like semaglutide and tirzepatide target areas of the brain that regulate appetite and food intake

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These include orlistat, liraglutide, and semaglutide (NICE TA875 for weight management in adults with obesity), as well as GLP-1 receptor agonists within the framework of NICE NG28 (type 2 diabetes management)