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Persistence of the SARS-CoV-2 virus can trigger a dysregulation of the immune system, followed by increased release of inflammatory cytokines and abnormal endothelial damage, ultimately leading to the development of chronic inflammation, vascular damage, hypercoagulability, microthrombosis, and multiorgan symptoms (68)
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The poor clinical outcomes are largely attributed to the tumor’s intrinsic resistance to therapy, driven by factors such as blood-brain barrier (BBB) impermeability, cellular heterogeneity, and the persistence of glioma stem cells (GSCs)