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In fact, in order to exert positive effects, they should be capable of preserving viability during storage and of colonizing gut, oral cavity or vaginal mucosae after oral administration

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The glutamine metabolism-related proteins, such as GLS-1, glutamate dehydrogenase (GDH), and ASCT2 were found to be highly expressed in HER2-positive breast cancer than other subtypes, which indicated that HER2-positive breast cancer had the highest glutamine metabolism activity ( One-carbon metabolism, also known as network of folate utilization reactions, participates in multiple metabolic pathways such as amino acid biosynthesis and degradation, de novo nucleotide biosynthesis, and methylation and reductive metabolism (49)