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Recent experimental studies demonstrate that stabilizing mast cells with cromolyn after ischemic stroke reduces peripheral and central inflammation, preserves gut barrier integrity, mitigates dysbiosis, and improves functional outcomes, underscoring the pivotal role of gut-derived mast cells and histamine in post-stroke neuroinflammation ( 3.6.4 Interventions 3.6.4.1 Probiotics Gut dysbiosis has been increasingly recognized as a contributor to cardiovascular disease (CVD) pathogenesis through mechanisms involving systemic inflammation and metabolic disruption, with probiotics and prebiotics emerging as promising strategies to restore microbiota balance and improve cardiovascular markers such as LDL cholesterol and high-sensitivity C-reactive protein (hs-CRP
