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Stimulation of the receptors upon binding of its ligands, for example with interalia AGE, leads to the activation of several molecular signalling pathways, including the PI3K/AKT, JAK/STAT, NF-κB, Ras/MAPK, Rac1/cdc42, p44/p42, p38 and SAP/JNK/MAPK pathways, which contribute to the expression of transcription factors, such as NF-κB, STAT3, HIF-1α, AP-1 and CREB