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(2) DHODH: DHODH is a mitochondrial flavoprotein localized to the inner mitochondrial membrane, where it catalyzes the fourth and rate-limiting step of de novo pyrimidine biosynthesis—the oxidation of dihydroorotate to orotate 42,43

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Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation , Beijing, China: Social Science Electronic Publishing