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Additionally, irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, abdominal discomfort and abnormal bowel habits, such as diarrhea or constipation, which are caused by changes in intestinal sensitivity and gastrointestinal motility [199]
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In short, chalcone and its derivatives exhibited antibacterial actions via various targets, which mainly include efflux pump inhibitory (EPI), interfering DNA replication, and filamentous temperature-sensitive mutant Z (FtsZ)