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4 Anticancer mechanism of selenium Selenium primarily manifests its chemopreventive properties by ensuring proper redox equilibrium and preventing the accumulation of misfolded proteins, largely through the action of selenoproteins such as glutathione peroxidases (GPxs), thioredoxin reductases (TrxRs), and selenoprotein P, which safeguard DNA from oxidative, mutagenic stresses (121)

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The association between the GSH and 25(OH)VD statuses is unlikely to be non-specific [1]