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Based on these simple observations and other experiments, a decrease in O 2 affinity was observed to enhance tissue O 2 delivery ( Although these and other data support the possible use of inositol hexaphosphate-loaded erythrocytes as effective treatments to improve the delivery of O 2 to tissues in need, there is an ongoing debate about the advantages of higher or lower hemoglobin–oxygen affinity in humans, particularly during hypoxia (Webb et al., 2021) that require further investigations

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