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There are also other paracrine factors and hormones that can impact melanin synthesis by altering intracellular cAMP ( via signal transduction cascades but instead have a defined function at the melanosome, the organelle responsible for making melanin ( OCA2 , SLC45A2 , and TPC2 affect baseline pigmentation and when the proteins they encode are non-functional, diseases of pigmentation such as albinism occur ( Figure 1 ) ( Non-canonical regulation of melanin synthesis via alteration of melanosomal pH There are two cAMP pathways that can regulate melanogenesis: a canonical and a non-canonical pathway

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coenzyme Q10 (CoQ10) acts as a lipophilic radical-trapping antioxidant inhibiting the spread of lipid peroxides