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Chang, a dermatologist and genome scientist, had discovered that the epigenome in aging skin, once it has accumulated enough marks, turns the genome on with a protein called NF-kB in ways that inflame and age skin

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P2X7R activation results in the release of pro-inflammatory cytokines IL-1β and IL-18 (He et al., 2017) which is mediated by the activation of nucleotide oligomerization domain containing protein 1 (NOD)-, leucine-rich repeat (LRR)-, and pyrin domain containing protein 3 (NLRP3) inflammasome complex (Iwata et al., 2016)