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Symptoms include: Neurological – confusion, altered gait, and peripheral neuropathy Bone Marrow- fatigue and shortness of breath due to megaloblastic anaemia Gastrointestinal – atrophic glossitis (red, beefy, smooth, and swollen tongue) Clinical Relevance Megaloblastic Anaemia In the cell cycle DNA and cytoplasmic maturation are co-ordinated ensuring cells can divide without losing key components