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Azelaic Acid primarily exerts its effects through anti-inflammatory and antimicrobial actions, while Tretinoin accelerates skin cell turnover and promotes collagen production

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In vitro pNPG processing assay The standard substrate p -nitrophenyl-β-D-glucuronide ( p NPG) was purchased as a solid (Sigma Aldrich) and resuspended in water to a concentration of 100 mM