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L-carnitine has been shown in preclinical studies to protect against kidney toxicity from cisplatin and ifosfamide (Sayed-Ahmed 2010

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Finally, a Phase I/IIA clinical study of glutathione PEGylated liposomal doxorubicin (2B3-101) demonstrated antitumor activity in patients with brain metastases and high-grade gliomas without adverse neurotoxicity or cardiotoxicity, although long-term follow-up is unclear [263]