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The first in the chain of these oxygen radicals is superoxide anion, and it was the discovery in 1983 that superoxide generation, as stimulated by a variety of agents including the chemoattractant N -formyl-leucyl-phenylalanine ( f MLP), the complement component C5a, and the calcium ionophore A23187, was inhibited by adenosine that sparked an interest in the anti-inflammatory properties of adenosine [43,44]

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To address this, the United Nations team advocated for locally managed “mobile training units” to actively engage miners