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For retatrutide , the 2023 New England Journal of Medicine phase 2 trial used doses of up to 12 mg weekly, with a structured escalation schedule beginning at lower doses and increasing incrementally over a period of weeks

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Introduction It is well-known that the brain is susceptible to oxidative stress, for reasons including high metabolic needs, oxidative stress associated with the production and storage of neurotransmitters, and sparse antioxidant defenses (Cobley et al., 2018)