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In 1996, when the survey was repeated again in the same area, awareness and use of oral vitamin B12 for pernicious anemia had increased substantially (0–19%), but the majority of doctors still remain unaware of this treatment option (61%) (8)

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All the crystal structures were obtained in complex with a heterologously expressed, synthetic version of 9D5 antibody fragment (Fab) that was previously used to crystallize the dDAT 16,26,35 (Supplementary Fig