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As renal function deteriorates (indicated here by an increase in serum creatinine concentration), the target range for plasma phenytoin concentration falls from 40-80 µmol/l when renal function is normal to 10-30 µmol/l in severe renal insufficiency

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Nrf2 Deficiency exacerbates obesity-Induced oxidative stress, neurovascular dysfunction, blood-brain barrier disruption, Neuroinflammation, Amyloidogenic Gene expression, and Cognitive decline in mice, mimicking the aging phenotype

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