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First, the mechanisms underlying neurodegenerative diseases are complex, necessitating a multi-targeted, comprehensive intervention rather than a sole reliance on antioxidants [84]

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Consistent with these insights, it has been reported that alpha-ketoglutaric acid (αKG), produced from isocitrate catalyzed by isocitrate dehydrogenase (IDH), and its downstream metabolites including succinic acid, fumaric acid, and malic acid, can displace the function of glutamine in the accumulation of lipid ROS and cystine starvation induced or system Xc − inhibition induced ferroptosis [25, 38, 39]

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