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Nrf2 functions by blocking GSH depletion-mediated lipid peroxidation in HCC cells and plays a central role in protecting them from sorafenib-induced ferroptosis (Sun et al., 2016b)

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2021), and, in ovarian cancer, the cytotoxic DNA-damaging agent cisplatin by inhibiting CBS, thus reducing glutathione and metallothionein, which may be implicated in cisplatin resistance (Kawahara, Ramadoss et al