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3.6 Leaky gut Disruption of intestinal barrier integrity, commonly referred to as “leaky gut” has emerged as a key pathogenic factor in a wide range of chronic inflammatory and autoimmune diseases (Hollander and Kaunitz, 2020)

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14 A recently published prospective placebo-controlled clinical trial involving 181 people with RRMS who were treated with a high oral dose of vitamin D 3 , a precursor of 1,25-dihydroxyvitamin D, (100,000 IU every other week) did not demonstrate any decrease in ARR during the 96-week-long study, however