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455 Their role in targeting GBM angiogenesis has also been explored, with miRNA-29a-3p-enriched MSC-derived EVs suppressing vasculogenic mimicry and angiogenesis independently of VEGF, suggesting a promising antiangiogenic strategy

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More recently, reticular pseudodrusen have been introduced as third macula risk feature of the disease, [13] associated with increased risk of progression, and incorporated in a new severity scale proposed by the AREDS and AREDS2 Research Groups [14]