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The analysis of polymorphonuclear neutrophils (oPMN) in the oral cavity showed that compared with the periodontal healthy control group, the expression of Nrf2 in patients with severe chronic periodontitis was significantly reduced, and the Nrf2 knockout mice showed severe local oxidative damage and increased alveolar bone and attachment loss at the site of periodontitis (63)

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showed a protective and therapeutic effect against streptozotocin-induced diabetes mellitus after 21 days of treatment