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First, we dissect the molecular mechanisms and dual roles of eight key RCD pathways—apoptosis, autophagy, necroptosis, ferroptosis, cuproptosis, pyroptosis, ICD, and lysosome-dependent cell death—in tumor progression and drug resistance, with a primary focus on NSCLC while noting subtype-specific vulnerabilities where evidence is clear (e.g., the unique sensitivity of EGFR-mutant tumors to ferroptosis)