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Taken together, except for hif-1 mRNA, mRNA accumulation of the stress-responsive transcription factors analyzed was modulated by glucose treatment: it was increased for crh-1 and sbp-1 , and was decreased for cep-1 , skn-1 , and daf-16 , probably as part of a mechanism in which several signaling pathways participate to regain homeostasis in worms fed a HGD

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It plays a vital role in supporting the body's production of glutathione, which performs many functions throughout the body