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In addition, we observed that most of the putative enhancers that were restored by SF had the expression of their associated DEG restored, suggesting that enhancer dynamics contribute to the glucose-induced transcriptional alterations, and that one of the mechanisms of SF-mediated reversal of the transcriptional memory is through reversal of epigenetic changes in genome regulatory regions, such as enhancers

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These are growth hormone releasers, peptides that prompt the pituitary to secrete more of the body’s own GH