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These other membrane-associated phospholipids are, instead, reduced by GPx-4, which has a preferential association with membranes and appears to have a minimal effect on intracellular hydrogen peroxide tone (320, 359), although from an enzymological point of view, GPx-4 is no less efficient than GPx-1 in reducing hydrogen peroxide or fatty acid hydroperoxides

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52 Class I variants have very severe enzyme deficiency (less than 10% to.20% of normal) and have chronic hemolytic anemia