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Prior observations that support neuronal ferroptosis in AD are that iron is associated with cognitive decline in several longitudinal clinical cohorts [2, 14,15,16,17,18,19, 42], that glutathione is depleted in AD brain tissue [29,30,31], and that downstream products of lipid peroxides such as 4-hydroxynonenal, malondialdehyde, F 2 -isoprostanes, acrolein, together with depletion of long-chain PUFAs, are features of AD brain tissue [36,37,38,39,40,41]
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