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228,229,230 Inhibiting xCT The search for strategies and drugs aimed at inducing oxidative stress has revealed xCT to be a suitable target—increased glutamate efflux through this antiporter is an important process for cells to generate sufficient glutathione to cope with high intracellular ROS levels

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Jerjes et al., 2006) in ME/CFS, indicating that HPA axis hypofunction represents an important neuroendocrine feature of the disorder

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