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(5) A comprehensive assessment of the safety, stability and long-term effects of excipients and polymers utilized in novel delivery systems is required

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For example, increased ubiquitylation of proteins belonging to catabolic processes such as alcohol dehydrogenase 5 (ADH5), an enzyme involved in glutathione-dependent formaldehyde detoxification pathway and maintaining redox balance in cells 42 was observed under both aging and following DUB inhibition (Fig