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Notably, mutations in PROP1 (Prop1df/df, Ames dwarf mice) and POU1F1 (Pou1f1dw/dw, Snell dwarf mice) disrupt anterior pituitary development, leading to deficiencies in GH, thyroid-stimulating hormone (TSH), and prolactin (PRL), significantly extending lifespan (Junnila et al., 2013)

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Vitamin C is an essential coenzyme in certain metabolic processes, particularly in the metabolism of the amino acids Tyrosine and Phenylalanine, collagen synthesis in ligaments, tendons and joint cartilage, synthesis of L-Carnitine, red blood cell formation, and modulating immune responses, as well as in the maintenance of healthy skin